Facilitation of transmitter release in a kinetic 2-gate model. Left-hand column shows stimulation at 50 Hz. Right-hand column shows release and gating transients at the tenth pulse. Fast gate: k+1 = 200 /mM.ms, k−1 = 3 /ms; Slow gate: k+2 = 0.25 /mM.ms, k−2 = 0.01 /ms; square-wave [Ca2+]r pulse: 1 mM amplitude, 1 ms duration.
