Complete stochastic synapse model
Submitted by bruce on Mon, 07/04/2011 - 08:56
Three distinct trials of a complete synapse model with 500 independent active zones. Each active zone uses the stochastic vesicle-state model of short-term synaptic dynamics combined with the 2-gate kinetic model of AMPA receptors. Phenomenological model of facilitation: p0 = 0.2; Δp = 0.05; τf = 100 ms. Vesicle-state model: k∗n = kr = 0.2 s−1; ns = 0. 2-gate kinetic receptor model: α = 4 mM−1ms−1, β = 1 ms−1. Esyn = 0 mV, with postsynaptic cell clamped at −65 mV. Synapse stimulated at 100Hz.
Code file:
Figure:
Chapter:
7
Notes:
A different result appears each time you run the simulation, since it is a stochastic model.
Simulation environment:
Figure number:
12