Figure 7.12

Three distinct trials of a complete synapse model with 500 independent active zones. Each active zone uses the stochastic vesicle-state model of short-term synaptic dynamics combined with the 2-gate kinetic model of AMPA receptors. Phenomenological model of facilitation: p₀ = 0.2; Δp = 0.05; τ_f = 100 ms. Vesicle-state model: k^∗_n = k_r = 0.2 s⁻¹; n_s = 0. 2-gate kinetic receptor model: α = 4 mM⁻¹ms⁻¹, β = 1 ms⁻¹. E_syn = 0 mV, with postsynaptic cell clamped at −65 mV. Synapse stimulated at 100Hz.