Postsynaptic current in response to 100Hz stimulation from (a) 2-gate kinetic receptor model, α = 4 /mM.ms, β = 1 /ms; (b) 5-gate desensitising model, Rb = 13 /mM.ms, Ru1 = 0.3 /ms, Ru2 = 200 /ms, Rd = 10 /ms, Rr = 0.02 /ms, Ro = 100 /ms, Rc = 1 /ms. Each presynaptic action potential is assumed to result in the release of a vesicle of neurotransmitter, giving a square-wave transmitter pulse amplitude of 1 mM and duration of 1 ms. The current is calculated as Isyn(t) = gsyn(t)(V(t) − Esyn). Esyn = 0 mV and the cell is clamped at −65 mV. The value of gsyn(t) approaches 0.8 nS on the first pulse.
